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The NBS/Harvard VI multi-room fire model was used to simulate results of previously reported full-scale multi-room fire experiments. The tests and simulations involved: four different compartment configurations of two or three rooms connected by open doorways, four different fire types generated by a methane burner and up to four different doorway openings between the burn room and adjacent space. A total of nineteen different tests were carried out and simulated. Selected comparisons between simulated and measured parameters of the fire-generated environments are reviewed. While the computer code is found to provide generally favorable simulations for the entire range of tests, several areas of modeling detail are identified for further improvement.